Authored on 24 January 2024 by Dr Ruch Karunadasa,
Reviewed 24 January 2024 by Dr Adeel Arshad.
Understanding GLP-1/GIP: A Guide to Dual-Action Weight Loss Treatments
A groundbreaking treatment is making waves in the UK, offering new solution options for individuals with type 2 diabetes and obesity aiming for substantial weight reduction.
Tirzepatide stands out as a pioneering medication by targeting two specific receptors: the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor, facilitating significant weight loss in patients.
More well-known medications like Semaglutide focus on a single receptor. This raises the question: how do Tirzepatide and Semaglutide differ and what does the targeting of receptors GIP and GLP-1 do?
What is GLP-1
GLP-1, or glucagon-like peptide-1, is a hormone integral to appetite regulation and insulin secretion. Leveraging this pathway, treatments can effectively curb hunger and enhance satiety, ultimately reducing caloric intake.
What is GIP
GIP, or glucose-dependent insulinotropic polypeptide, plays a pivotal role in blood sugar regulation and fat metabolism. It's key in encouraging fat reduction and preventing fat accumulation, positioning it as a critical component in weight management strategies.
Introducing Mounjaro: A Dual-Action Approach
Mounjaro represents a revolutionary treatment that targets both the GLP-1 and GIP pathways. This dual-action strategy not only moderates appetite but also modulates body fat utilisation. These improvements can reduce the risk of heart disease, kidney disease , forms of fatty liver disease as well as type 2 diabetes. With the synergistic effects of GLP-1 and GIP agonists, Mounjaro delivers a holistic approach to weight management.
What is best? GLP-1 Alone vs GLP-1/GIP Combination
Currently, there are no direct comparison trials published. However, when analysing clinical trials for both GLP-1/GIP treatments and GLP-1 only treatments, patients receiving GLP-1/GIP alongside diet and lifestyle changes achieved a 20.9% weight loss at 72 weeks, compared to a 14.9% weight loss at 68 weeks for those on GLP-1 only treatments.
The choice between GLP-1 alone and GLP-1/GIP combination treatments depends on individual needs and medical advice.
References and footnotes
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